Number of the records: 1
Omne vivum ex ovo: the oocyte reprogramming and remodeling activities
- 1.0580371 - ÚEM 2024 RIV GB eng J - Journal Article
Fulka, Helena - Loi, P. - Czernik, M. - Surani, A. - Fulka Jr, J.
Omne vivum ex ovo: the oocyte reprogramming and remodeling activities.
Reproduction. Roč. 165, č. 3 (2023), R75-R89. ISSN 1470-1626. E-ISSN 1741-7899
R&D Projects: GA ČR(CZ) GF21-42225L
Institutional support: RVO:68378041
Keywords : topologically associating domains * zygotic genome activation * full-term development * nuclear transfer
OECD category: Reproductive biology (medical aspects to be 3)
Impact factor: 3.7, year: 2023
Method of publishing: Open access
https://rep.bioscientifica.com/view/journals/rep/165/3/REP-22-0124.xml
The mammalian oocyte is a unique cell, and comprehending its physiology and biology is essential for understanding fertilization, totipotency and early events of embryogenesis. Consequently, research in these areas influences the outcomes of various technologies, for example, the production and conservation of laboratory and large animals with rare and valuable genotypes, the rescue of the species near extinction, as well as success in human assisted reproduction. Nevertheless, even the most advanced and sophisticated reproductive technologies of today do not always guarantee a favorable outcome. Elucidating the interactions of oocyte components with its natural partner cell - the sperm or an 'unnatural' somatic nucleus, when the somatic cell nucleus transfer is used is essential for understanding how totipotency is established and thus defining the requirements for normal development. One of the crucial aspects is the stoichiometry of different reprogramming and remodeling factors present in the oocyte and their balance. Here, we discuss how these factors, in combination, may lead to the formation of a new organism. We focus on the laboratory mouse and its genetic models, as this species has been instrumental in shaping our understanding of early post-fertilization events.
Permanent Link: https://hdl.handle.net/11104/0351130
Number of the records: 1