Advantages of polar organic solvent chromatography for enantioseparation of chiral liquid crystals

0580266 - FZÚ 2024 RIV NL eng J - Journal Article
Vaňkátová, Petra - Kalíková, K. - Kubíčková, A.
Advantages of polar organic solvent chromatography for enantioseparation of chiral liquid crystals.
Journal of Chromatography A. Roč. 1709, Oct (2023), č. článku 464383. ISSN 0021-9673. E-ISSN 1873-3778
R&D Projects: GA ČR(CZ) GA22-16499S
Institutional support: RVO:68378271
Keywords : chiral resolution * liquid crystal * enantioseparation * liquid chromatography * polysaccharidebased chiral selector
OECD category: Analytical chemistry
Impact factor: 4.1, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.chroma.2023.464383

Three sets of fluorinated chiral liquid crystals were used to explore the polar organic solvent chromatography mode for their enantioseparation. The materials include a set of newly synthesized compounds with chiral center derived from 2-hexanol and two sets of compounds with chiral center derived from 2-/3-octanol. Baseline enantioseparation of all materials was achieved using binary mobile phases without additives.The mobile phases tested included whole range of acetonitrile/methanol mixtures to demonstrate that acetonitrile-rich and alcohol-rich mobile phases offer different enantiorecognition mechanisms and can provide complementarity to some extent. The effect of temperature on enantioseparation was investigated on Chiralpak IA-U by constructing van’t Hoff plots for selected liquid crystals in pure acetonitrile and pure methanol as mobile phases.
Permanent Link: https://hdl.handle.net/11104/0349019