Determination and Characterization of Psychoactive Drugs. Elucidation of their Metabolic Processes

0579989 - ÚFCH JH 2024 PK eng C - Conference Paper (international conference)
Hrdlička, Vojtěch - Jerga, R. - Choińska-Mlynarczyk, Marta - Skopalová, J. - Langmaier, Jan - Šelešovská, R. - Navrátil, Tomáš
Determination and Characterization of Psychoactive Drugs. Elucidation of their Metabolic Processes.
3rd International Conference on Biological Research & Applied Sciences (IBRAS). Karachi: Jinnah University for Women, 2023, s. 102-104.
[International Conference on Biological Research & Applied Sciences (IBRAS) /3./. Karachi (PK), 17.01.2023-19.01.2023]
R&D Projects: GA ČR(CZ) GA20-07350S
Institutional support: RVO:61388955
Keywords : electrochemistry * active pharmaceutical ingredient * environment
OECD category: Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
https://www.juw.edu.pk/conference/ibras-2023/6-%20Chemistry/1-Tomas%20Navratil.pdf

Psychoactive drugs (PDs) belong generally to the most commonly (mis)used substances worldwide. Determination and monitoring of their active pharmaceutical ingredients (APIs) and their respective metabolites in body fluids and environmental matrices present a challenge for analytical chemists. Our research is focused on the most frequently prescribed and on newly introduced psychoactive drugs of specified structures and/or defined properties. Emphasis was placed on the investigation of the reaction mechanisms of metabolite formation. New and alternative methods to the commonly used electroanalytical methods applicable for the analysis and characterization of target compounds in the pure state, in body fluids, wastewaters, or other matrices, have been developed. If possible, the applied electrochemical techniques are combined with others (mass spectroscopy, chromatography, etc.). To improve the chemometric parameters and sensing characteristics, attention is paid to the construction of new electrochemical sensors and detectors.
Permanent Link: https://hdl.handle.net/11104/0348777