Bioorthogonal Chemistry in Cellular Organelles

0579956 - ÚOCHB 2025 RIV CH eng J - Journal Article
Šlachtová, Veronika - Chovanec, Marek - Rahm, Michal - Vrábel, Milan
Bioorthogonal Chemistry in Cellular Organelles.
Topics in Current Chemistry. Roč. 382, č. 1 (2024), č. článku 2. ISSN 2365-0869. E-ISSN 2364-8961
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA ČR(CZ) GF20-30494L
Institutional support: RVO:61388963
Keywords : bioorthogonal reactions * bioconjugations * cellular organelles * click chemistry * targeting
OECD category: Organic chemistry
Impact factor: 8.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1007/s41061-023-00446-5

While bioorthogonal reactions are routinely employed in living cells and organisms, their application within individual organelles remains limited. In this review, we highlight diverse examples of bioorthogonal reactions used to investigate the roles of biomolecules and biological processes as well as advanced imaging techniques within cellular organelles. These innovations hold great promise for therapeutic interventions in personalized medicine and precision therapies. We also address existing challenges related to the selectivity and trafficking of subcellular dynamics. Organelle-targeted bioorthogonal reactions have the potential to significantly advance our understanding of cellular organization and function, provide new pathways for basic research and clinical applications, and shape the direction of cell biology and medical research.
Permanent Link: https://hdl.handle.net/11104/0348749