INFLUENCE OF RESPIRATORY TRACT CONDITIONS ON PARTICLE SIZE DISTRIBUTIONS GENERATED BY COMMERCIALLY AVAILABLE INHALERS

0579895 - ÚCHP 2024 RIV CZ eng C - Conference Paper (international conference)
Mašková, Ludmila - Ždímal, Vladimír - Ondráček, Jakub
INFLUENCE OF RESPIRATORY TRACT CONDITIONS ON PARTICLE SIZE DISTRIBUTIONS GENERATED BY COMMERCIALLY AVAILABLE INHALERS.
SBORNÍK XXII. VÝROČNÍ KONFERENCE ČESKÉ AEROSOLOVÉ SPOLEČNOSTI. Praha: Česká aerosolová společnost, z.s, 2023 - (Suchánková, L.), s. 61-62. ISBN 978-80-908653-1-0.
[VÝROČNÍ KONFERENCE ČESKÉ AEROSOLOVÉ SPOLEČNOSTI /22./. Čeladná (CZ), 13.11.2023-14.11.2023]
R&D Projects: GA MŠMT(CZ) LTC17010
EU Projects: European Commission(XE) MP1404 - COST Action
Institutional support: RVO:67985858
Keywords : number size distribution * inhaler * hygroscopicity
OECD category: Environmental sciences (social aspects to be 5.7)

Pressurized metered dose inhalers (MDI) and dry powder inhalers (DPI) are an integral part of the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) (Vichrow et al., 2008). An important characteristic of particles dosed by MDI and DPI is particle size distribution (PSD) (Byron, 1990). This may vary depending on the formulation, but also on the temperature and relative humidity (RH) changes during the transport from the inhaler to the human respiratory tract. The aim of this study was to determine the influence of RH and inspiratory flow rates on the PSD
characteristics and predict deposition efficiency of inhalable particles in the lungs.
Permanent Link: https://hdl.handle.net/11104/0348681