Trypanosomes as a magnifying glass for cell and molecular biology

0579778 - BC 2024 RIV NL eng J - Journal Article
Lukeš, Julius - Speijer, D. - Zíková, Alena - Alfonzo, J. D. - Hashimi, Hassan - Field, Mark Christian
Trypanosomes as a magnifying glass for cell and molecular biology.
Trends in Parasitology. Roč. 39, č. 11 (2023), s. 902-912. ISSN 1471-4922. E-ISSN 1471-5007
R&D Projects: GA ČR(CZ) GA23-07674S; GA ČR(CZ) GX23-06479X; GA ČR(CZ) GA20-14409S
EU Projects: European Commission(XE) 101044951 - MitoSignal; Wellcome Trust(GB) 204697/Z/16/Z
Grant - others:Gordon and Betty Moore Foundation(US) GBMF9354
Program: Science
Institutional support: RVO:60077344
Keywords : variant surface glycoprotein * double-stranded-rna * alternative oxidase * sleeping sickness * brucei * mitochondria * import * localization * degradation * peroxisomes
OECD category: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Impact factor: 9.6, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S1471492223001952?via%3Dihub

The African trypanosome, Trypanosoma brucei, has developed into a flexible and robust experimental model for molecular and cellular parasitology, allowing us to better combat these and related parasites that cause worldwide suffering. Diminishing case numbers, due to efficient public health efforts, and recent de-velopment of new drug treatments have reduced the need for continued study of T. brucei in a disease context. However, we argue that this pathogen has been instrumental in revolutionary discoveries that have widely informed molec-ular and cellular biology and justifies continuing research as an experimental model. Ongoing work continues to contribute towards greater understanding of both diversified and conserved biological features. We discuss multiple examples where trypanosomes pushed the boundaries of cell biology and hope to inspire researchers to continue exploring these remarkable protists as tools for magnifying the inner workings of cells.
Permanent Link: https://hdl.handle.net/11104/0348589