Selected Plant Triterpenoids and Their Derivatives as Antiviral Agents

0579197 - ÚEB 2024 RIV CH eng J - Journal Article
Wimmerová, Martina - Bildziukevich, Uladzimir - Wimmer, Zdeněk
Selected Plant Triterpenoids and Their Derivatives as Antiviral Agents.
Molecules. Roč. 28, č. 23 (2023), č. článku 7718. E-ISSN 1420-3049
Institutional support: RVO:61389030
Keywords : plant triterpenoid * structure modifier * antiviral activity
OECD category: Chemical engineering (plants, products)
Impact factor: 4.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/molecules28237718

The results of the most recent investigation of triterpenoid-based antiviral agents namely in the HIV-1 and HSV-1 treatment were reviewed and summarized. Several key historical achievements are included to stress consequences and continuity in this research. Most of the agents studied belong to a series of compounds derived from betulin or betulinic acid, and their synthetic derivative is called bevirimat. A termination of clinical trials of bevirimat in Phase IIb initiated a search for more successful compounds partly derived from bevirimat or designed independently of bevirimat structure. Surprisingly, a majority of bevirimat mimics are derivatives of betulinic acid, while other plant triterpenoids, such as ursolic acid, oleanolic acid, glycyrrhetinic acid, or other miscellaneous triterpenoids, are relatively rarely involved in a search for a novel antiviral agent. Therefore, this review article is divided into three parts based on the leading triterpenoid core structure.
Permanent Link: https://hdl.handle.net/11104/0348046