0578987 - MBÚ 2024 RIV US eng J - Journal Article
Saati-Santamaria, Zaki - Baroncelli, R. - Rivas, R. - Garcia-Fraile, P.
Comparative Genomics of the Genus Pseudomonas Reveals Host- and Environment-Specific Evolution.
Microbiology Spectrum. Roč. 10, č. 6 (2022), č. článku 02370-22. ISSN 2165-0497. E-ISSN 2165-0497
Institutional support: RVO:61388971
Keywords : adaptation * bacteria * sequence * Pseudomonas * environmental microbiology * genomics * host-cell interactions * microbial ecology
OECD category: Microbiology
Impact factor: 3.7, year: 2022
Method of publishing: Open access
https://journals.asm.org/doi/10.1128/spectrum.02370-22

Each Earth ecosystem has unique microbial communities. Pseudomonas bacteria have evolved to occupy a plethora of different ecological niches, including living hosts, such as animals and plants. Many genes necessary for the Pseudomonas-niche interaction and their encoded functions remain unknown. Here, we describe a comparative genomic study of 3,274 genomes with 19,056,667 protein-coding sequences from Pseudomonas strains isolated from diverse environments. We detected functional divergence of Pseudomonas that depends on the niche. Each group of strains from a certain environment harbored a distinctive set of metabolic pathways or functions. The horizontal transfer of genes, which mainly proceeded between closely related taxa, was dependent on the isolation source. Finally, we detected thousands of undescribed proteins and functions associated with each Pseudomonas lifestyle. This research represents an effort to reveal the mechanisms underlying the ecology, pathogenicity, and evolution of Pseudomonas, and it will enable clinical, ecological, and biotechnological advances.
Permanent Link: https://hdl.handle.net/11104/0347873