Structure and inhibition of monkeypox virus methyltransferase VP39

0578951 - ÚOCHB 2024 RIV CZ eng A - Abstract
Klíma, Martin - Šilhán, Jan - Škvára, Petr - Chalupská, Dominika - Otava, Tomáš - Zgarbová, Michala - Weber, Jan - Nencka, Radim - Bouřa, Evžen
Structure and inhibition of monkeypox virus methyltransferase VP39.
Czech Chemical Society Symposium Series. Roč. 21, č. 5 (2023), s. 181. ISSN 2336-7202.
[Annual meeting of the National Institute of Virology and Bacteriology (NIVB) /2./. 02.10.2023-05.10.2023, Kutná Hora]
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : monkeypox virus * antivirals
OECD category: Virology
http://www.ccsss.cz/index.php/ccsss/issue/view/41/75

Monkeypox is a zoonotic disease with pandemic potential. It is caused by the monkeypox virus (MPXV), adouble-stranded DNA virus from the Poxviridae family. MPXV replicates in cytoplasm and thus, it must encode for the DNA/RNA replication machinery. Besides the DNA-dependent DNA and RNA polymerases, it also encodes for the RNA capping enzymes. In poxviruses, the RNA cap is crucial for the translation and stability of viral RNA and for immune evasion. One of the key components of the monkeypox virus RNA capping machinery is the RNA methyltransferase (MTase) VP39.
Permanent Link: https://hdl.handle.net/11104/0347854