Design and synthesis of new molecular tools to probe cytosolic proteins in bacteria resistant to rifamycin antibiotics

0578949 - ÚOCHB 2024 RIV CZ eng A - Abstract
Mojr, Viktor - Sudzinová, Petra - Hubálek, Martin - Krásný, Libor - Rejman, Dominik
Design and synthesis of new molecular tools to probe cytosolic proteins in bacteria resistant to rifamycin antibiotics.
Czech Chemical Society Symposium Series. Roč. 21, č. 5 (2023), s. 179. ISSN 2336-7202.
[Annual meeting of the National Institute of Virology and Bacteriology (NIVB) /2./. 02.10.2023-05.10.2023, Kutná Hora]
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963 ; RVO:61388971
Keywords : rifamycin * resistance
OECD category: Organic chemistry; Microbiology (MBU-M)
http://www.ccsss.cz/index.php/ccsss/issue/view/41/75

Rifamycin-derived antibiotics are highly efficient inhibitors of prokaryotic DNA-dependent RNA polymerase (RNAP) used in treatment of many bacterial infections, including tuberculosis. During exposure, however, bacteria develop resistance to antibiotics, and several modifications of rifamycin skeleton that inhibit RNAP binding have already been discovered. A photo-crosslinking probe 1(Fig. 1) with biotin handle based on rifamycin B was recently used for identifying specific protein that displaces antibiotic from RNAP in Streptomyces venezulae.
Permanent Link: https://hdl.handle.net/11104/0347852