Plasmodesmata mediate cell-to-cell transport of brassinosteroid hormones

0578396 - ÚEB 2024 RIV US eng J - Journal Article
Wang, Y. - Perez-Sancho, J. - Platre, M.P. - Callebaut, D. - Smokvarska, M. - Ferrer, Karoll - Luo, Y. - Nolan, T. - Sato, T. - Busch, W. - Benfey, P. - Kvasnica, Miroslav - Winne, J. M. - Bayer, E. M. - Vukašinović, N. - Russinova, E.
Plasmodesmata mediate cell-to-cell transport of brassinosteroid hormones.
Nature Chemical Biology. Roč. 19, č. 11 (2023), s. 1331-1341. ISSN 1552-4450. E-ISSN 1552-4469
R&D Projects: GA MŠMT(CZ) EF16_019/0000827
Institutional support: RVO:61389030
Keywords : ARABIDOPSIS * PROTEIN * BIOSYNTHESIS
OECD category: Biochemistry and molecular biology
Impact factor: 14.8, year: 2022
Method of publishing: Open access
https://doi.org/10.1038/s41589-023-01346-x

Brassinosteroids (BRs) are steroidal phytohormones that are essential for plant growth, development and adaptation to environmental stresses. BRs act in a dose-dependent manner and do not travel over long distances, hence, BR homeostasis maintenance is critical for their function. Biosynthesis of bioactive BRs relies on the cell-to-cell movement of hormone precursors. However, the mechanism of the short-distance BR transport is unknown, and its contribution to the control of endogenous BR levels remains unexplored. Here we demonstrate that plasmodesmata (PD) mediate the passage of BRs between neighboring cells. Intracellular BR content, in turn, is capable of modulating PD permeability to optimize its own mobility, thereby manipulating BR biosynthesis and signaling. Our work uncovers a thus far unknown mode of steroid transport in eukaryotes and exposes an additional layer of BR homeostasis regulation in plants.
Permanent Link: https://hdl.handle.net/11104/0347394