Pentacoordinate mixed-ligand Zn(II) complexes with flufenamato and niflumato ligands: crystal structure, spectral characterization and biological properties

0577700 - FZÚ 2024 RIV CH eng J - Journal Article
Smolková, R. - Smolko, L. - Poupon, Morgane - Samoľová, Erika
Pentacoordinate mixed-ligand Zn(II) complexes with flufenamato and niflumato ligands: crystal structure, spectral characterization and biological properties.
Crystals. Roč. 13, č. 10 (2023), č. článku 1460. ISSN 2073-4352. E-ISSN 2073-4352
R&D Projects: GA MŠMT LM2023065
Institutional support: RVO:68378271
Keywords : zinc * NSAID * X-ray diffraction * fluorescence * Hirshfeld surface
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 2.7, year: 2022
Method of publishing: Open access

Mixed-ligand complexes featuring a carboxylato ligand and bidentate chelate N,N'-donor ligands along with a single halogenido ligand are rarely subjected to studies despite their interesting physical, chemical and biological properties. A direct synthesis involving non-steroidal anti-inflammatory drugs flufenamic acid and niflumic acid and sterically hindering N,N'-donor ligands (neocuproine and 2,2'-biquinoline) has been used to prepare mononuclear mixed-ligand zinc complexes with a composition of [ZnCl(flu)(neo)] (1A and 1B) and [ZnCl(nif )(biq)] (2). Single-crystal X-ray diffraction data have shown that the carboxylate binding mode differs in the two polymorphs 1A and 1B, which form molecules of same composition, and the deviations in molecular geometry are further reflected in their supramolecular structures.
Permanent Link: https://hdl.handle.net/11104/0346821