Heteroleptic silver(I) and gold(I) N‑heterocyclic carbene complexes: structural characterization, computational analysis, tyrosinase inhibitory, and biological effects

0577698 - FZÚ 2024 RIV US eng J - Journal Article
Neshat, A. - Mahdavi, A. - Yousefshahi, M.R. - Cheraghi, M. - Eigner, Václav - Kučeráková, Monika - Dušek, Michal - Rezaie, F. - Kaboudin, B.
Heteroleptic silver(I) and gold(I) N‑heterocyclic carbene complexes: structural characterization, computational analysis, tyrosinase inhibitory, and biological effects.
Inorganic Chemistry. Roč. 62, č. 41 (2023), s. 16710-16724. ISSN 0020-1669. E-ISSN 1520-510X
R&D Projects: GA MŠMT(CZ) EF16_019/0000760
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : bacteria * ligands * metals * peptides and proteins * sulfur
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 4.6, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acs.inorgchem.3c01759

Derivatization of (NHC)M-Cl (M = Ag, Au) with selected sulfur donors from the family of dialkyldithiophosphates and bis(2-mercapto-1-methylimidazolyl)borate ligands gave a series of heteroleptic mononuclear complexes. In single-crystal X-ray diffraction analysis, Ag(I) complexes adopted a trigonal planar geometry, while Au(I) complexes are near-linear. TD-DFT and hole−electron analyses of the selected complexes gave insight into the electronic features of the metal complexes. In vitro cellular tests were conducted on the human cancerous breast cell line MCF-7 using 2 and 8. The antibacterial activities of complexes 1, 2, 3, 7, 8, and IPr−Ag-Cl were also screened against Gram-positive (Staphylococcus aureus PTCC 1112) and Gram-negative (Escherichia coli PTCC 1330) bacteria. Antityrosinase and hemolytic effects of the selected compounds were also determined.
Permanent Link: https://hdl.handle.net/11104/0346820