活化STING转接蛋白的具有膦酸酯键的2’3’环状二核苷酸

0577639 - ÚOCHB 2024 RIV chi P - Patent Document
Birkuš, Gabriel - Páv, Ondřej - Jandušík, Tomáš - Rosenberg, Ivan - Nencka, Radim
活化STING转接蛋白的具有膦酸酯键的2’3’环状二核苷酸.
[2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein.]
2023. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 12.09.2023. Patent Number: CN111511754. Territorial Protection: národní patent v zemi mimo EU ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : STING * cyclic dinucleotide * agonist
OECD category: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/065244413/publication/CN111511754B?q=CN111511754B

本发明涉及具有通式(J)的2'3'环状膦酸酯二核苷酸、其药学上可接受的盐、其医药组合物及所述物质与其他药剂或药品的组合。本发明还涉及所述化合物用于治疗或预防可通过STING蛋白质调节来改善的疾病或病状、诸如癌症或病毒性疾病、过敏性疾病及炎性疾病的用途。此外，这些物质可用作疫苗中的佐剂。

The present disclosure relates to 2′3′ cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
Permanent Link: https://hdl.handle.net/11104/0346768