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3α5ß-Neuroactive steroids for the treatment of epilepsy and seizure diseases
- 1.0577525 - ÚOCHB 2024 RIV eng P - Patent Document
Kudová, Eva - Chodounská, Hana - Mareš, Pavel - Valeš, Karel
3α5ß-Neuroactive steroids for the treatment of epilepsy and seizure diseases.
2023. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - Fyziologický ústav AV ČR, v. v. i. Date of the patent acceptance: 01.08.2023. Patent Number: CA3128921. Territorial Protection: národní patent v zemi mimo EU ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : pregnanolone * epilepsy * steroid
OECD category: Neurosciences (including psychophysiology
https://worldwide.espacenet.com/patent/search/family/070285346/publication/CA3128921C?q=CA3128921C
The invention provides 3α5β–steroid compounds of general formula I. These compounds are useful in the treatment of epilepsy or comorbidities associated with epilepsy or conditions associated with convulsions, such as seizures associated with hypoxia, seizures associated with traumatic brain damage, seizures associated with intoxication, pathological changes caused by hyperexcitation, or in treatment of conditions accompanying epilepsy, such as affective disorders, depression, post-traumatic stress disorder (PTSD) and stress-related diseases, anxiety, schizophrenia and psychotic disorders, related ischemic CNS damage, neurodegenerative changes and disorders, multiple sclerosis. The compounds of general formula I also show age-specific efficacy.
Permanent Link: https://hdl.handle.net/11104/0346645
Number of the records: 1