Biomarkers for Huntington's Disease

0577188 - ÚŽFG 2024 RIV CH eng M - Monography Chapter
Vodičková Kepková, Kateřina - Vodička, Petr
Mitochondrial/Oxidative Stress Biomarkers in Huntington’s Disease.
Biomarkers for Huntington's Disease. Cham: Springer, 2023 - (Thomas, E.; Parkin, G.), s. 321-350. Contemporary Clinical Neuroscience. ISBN 978-3-031-32814-5
R&D Projects: GA ČR GA22-24983S
Institutional support: RVO:67985904
Keywords : oxidative stress * Huntington´s disease
OECD category: Cell biology

Huntington’s disease (HD) is a hereditary neurodegeneration caused by a mutation in the HTT gene, leading to mutated huntingtin protein aggregation. This results in a widespread dysregulation of cellular pathways and death of medium spiny neurons of the striatum. Due to the high metabolic demand of brain tissue, mitochondrial dysfunction and resulting oxidative stress are common pathological features contributing to many neurodegenerative diseases, including HD. In this review, we summarize studies that measured fluid biomarkers of oxidative stress in HD patients. At the current state of knowledge, none of the reviewed biomarkers can be used as a reliable measure of HD progression or response to treatment in isolation. However, combining biomarkers covering different aspects of mitochondrial dysfunction and oxidative stress with HD specific biomarkers could be a more promising strategy.
Permanent Link: https://hdl.handle.net/11104/0346406