Biomarkers for Huntington's Disease

0577186 - ÚŽFG 2024 RIV CH eng M - Monography Chapter
Ananbeh, Hanadi - Kupcová Skalníková, Helena
Extracellular Vesicles as Possible Sources of Huntington’s Disease Biomarkers.
Biomarkers for Huntington's Disease. Cham: Springer, 2023 - (Thomas, E.; Parkin, G.), s. 45-75. Contemporary Clinical Neuroscience. ISBN 978-3-031-32814-5
R&D Projects: GA ČR(CZ) GA19-01747S
Institutional support: RVO:67985904
Keywords : extracellular vesicles * Huntington´s disease
OECD category: Biochemistry and molecular biology

Extracellular vesicles (EVs) are membrane enveloped particles released from cells to the extracellular environment and body fluids. During their biosynthesis, lipids, proteins, nucleic acids, metabolites and other molecules of the EV producing cell are incorporated into EVs. EVs are able to transfer such molecular cargo to recipient cells and thus participate in intercellular communication. In this chapter, we review the current knowledge about EVs in a rare hereditary neurodegenerative disorder, Huntington’s disease (HD), which is caused by expanded polyglutamine sequence in protein huntingtin. The roles of EVs in HD are presented from several aspects, including the roles of EVs in disease pathogenesis and transfer of mutant huntingtin, EV importance in the search of HD biomarkers with a special focus on proteins and miRNAs, and experimental therapeutic applications of astrocyte- and stem cell-derived EVs as well as engineered EVs in HD.
Permanent Link: https://hdl.handle.net/11104/0346405