Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation

0576684 - ÚOCHB 2024 RIV CH eng J - Journal Article
Vydra Boušová, Kristýna - Zouharová, Monika - Jirásková, Kateřina - Vetýšková, Veronika
Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation.
International Journal of Molecular Sciences. Roč. 24, č. 20 (2023), č. článku 15162. ISSN 1661-6596
Institutional support: RVO:61388963
Keywords : TRPM channels * calmodulin * calcium homeostasis * calmodulin binding site * regulation
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms242015162

Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular processes like calcium homeostasis. These channels exhibit complex regulation, and one of the key regulatory mechanisms involves their interaction with calmodulin (CaM), a cytosol ubiquitous calcium-binding protein. The association between TRPM channels and CaM relies on the presence of specific CaM-binding domains in the channel structure. Upon CaM binding, the channel undergoes direct and/or allosteric structural changes and triggers down- or up-stream signaling pathways. According to current knowledge, ion channel members TRPM2, TRPM3, TRPM4, and TRPM6 are directly modulated by CaM, resulting in their activation or inhibition. This review specifically focuses on the interplay between TRPM channels and CaM and summarizes the current known effects of CaM interactions and modulations on TRPM channels in cellular physiology.
Permanent Link: https://hdl.handle.net/11104/0346129