Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report

0576044 - ÚŽFG 2024 RIV US eng J - Journal Article
Ambrožová, L. - Zeman, Tomáš - Janout, V. - Janoutová, J. - Lochman, Jan - Šerý, Omar
Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report.
Journal of Clinical Laboratory Analysis. Roč. 37, č. 13-14 (2023), č. článku e24949. ISSN 0887-8013. E-ISSN 1098-2825
R&D Projects: GA MZd NT14504; GA MZd(CZ) NV18-04-00455
Grant - others:GA ČR(CZ) GP309/09/P361
Program: GP
Institutional support: RVO:67985904
Keywords : candidate gene analyses * genetic association study * insulin-degrading enzyme (IDE) * miRNA * schizophrenic disorder * single nucleotide polymorphism (SNP)
OECD category: Clinical neurology
Impact factor: 2.7, year: 2022
Method of publishing: Open access
https://onlinelibrary.wiley.com/doi/10.1002/jcla.24949

BackgroundInsulin-degrading enzyme (IDE) is an important gene in studies of the pathophysiology of type 2 diabetes mellitus (T2DM). Recent studies have suggested a possible link between type 2 diabetes mellitus (T2DM) and the pathophysiology of schizophrenia (SZ). At the same time, significant changes in insulin-degrading enzyme (IDE) gene expression have been found in the brains of people with schizophrenia. These findings highlight the need to further investigate the role of IDE in schizophrenia pathogenesis. MethodsWe enrolled 733 participants from the Czech Republic, including 383 patients with schizophrenia and 350 healthy controls. Our study focused on the single nucleotide polymorphism (SNP) rs2421943 in the IDE gene, which has previously been associated with the pathogenesis of Alzheimer's disease. The SNP was analyzed using the PCR-RFLP method. ResultsThe G allele of the rs2421943 polymorphism was found to significantly increase the risk of developing SZ (p < 0.01) when a gender-based analysis showed that both AG and GG genotypes were associated with a more than 1.55 times increased risk of SZ in females (p < 0.03) but not in males. Besides, we identified a potential binding site at the G allele locus for has-miR-7110-5p, providing a potential mechanism for the observed association. ConclusionOur results confirm the role of the IDE gene in schizophrenia pathogenesis and suggest that future research should investigate the relationship between miRNA and estrogen influence on IDE expression in schizophrenia pathogenesis.
Permanent Link: https://hdl.handle.net/11104/0345882