Coilin and Cajal bodies

0576034 - ÚMG 2024 RIV GB eng J - Journal Article
Staněk, David
Coilin and Cajal bodies.
Nucleus. Roč. 14, č. 1 (2023), č. článku 2256036. ISSN 1949-1034. E-ISSN 1949-1042
R&D Projects: GA ČR GA21-04132S
Institutional support: RVO:68378050
Keywords : Cajal bodies * coilin * snoRNA * snRNA * snRNP * telomerase RNA
OECD category: Biochemistry and molecular biology
Impact factor: 3.7, year: 2022
Method of publishing: Limited access
https://www.tandfonline.com/doi/full/10.1080/19491034.2023.2256036

The nucleus of higher eukaryotes contains a number of structures that concentrate specific biomolecules and play distinct roles in nuclear metabolism. In recent years, the molecular mechanisms controlling their formation have been intensively studied. In this brief review, I focus on coilin and Cajal bodies. Coilin is a key scaffolding protein of Cajal bodies that is evolutionarily conserved in metazoans. Cajal bodies are thought to be one of the archetypal nuclear structures involved in the metabolism of several short non-coding nuclear RNAs. Yet surprisingly little is known about the structure and function of coilin, and a comprehensive model to explain the origin of Cajal bodies is also lacking. Here, I summarize recent results on Cajal bodies and coilin and discuss them in the context of the last three decades of research in this field.
Permanent Link: https://hdl.handle.net/11104/0346942