Role of sigma factors of RNA polymerase in bacterial physiology, volume II

0576016 - MBÚ 2024 RIV CH eng J - Journal Article
Pátek, Miroslav - Manganelli, R. - Toyoda, K.
Role of sigma factors of RNA polymerase in bacterial physiology, volume II.
Frontiers in Microbiology. Roč. 14, June 12 (2023), č. článku 1220519. ISSN 1664-302X. E-ISSN 1664-302X
Institutional support: RVO:61388971
Keywords : Corynebacterium glutamicum * Mycobacterium tuberculosis * Listeria monocytogenes * Burkholderia * pathogen * sigma factor * promoter * stress
OECD category: Microbiology
Impact factor: 5.2, year: 2022
Method of publishing: Open access
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1220519/full

Gene expression in bacteria is controlled by three main types of protein regulators: DNA-binding transcriptional regulators, two-component systems, and sigma (σ) factors of RNA polymerase. Since RNA polymerase is essential for transcription, sigma factors, as its subunits are involved in the control of each gene. In many cases, the main regulators control the expression of a gene cooperatively. Bacteria contain between two and more than 60 different σ factors, depending on the species. One of these, usually called σ A, is responsible for the transcription of most housekeeping genes, while the others are alternative. A large number of σ factors induced in most bacteria by various stresses belong to group 4 of sigma factors, called extracytoplasmic function sigma factors (ECF σ). All four articles in this Research Topic are dedicated to this type of σ. Two articles describe original research, and two others are reviews. Three contributions deal with gram-positive bacteria (Corynebacterium glutamicum, Mycobacterium tuberculosis, and Listeria monocytogenes) and one with a gram-negative bacterium (Burkholderia sp.)
Permanent Link: https://hdl.handle.net/11104/0352004