GC–MS analysis and pharmacological evaluations of Phoenix sylvestris (Roxb.) seeds provide new insights into the management of oxidative stress and hyperglycemia

0575820 - ÚEB 2024 RIV US eng J - Journal Article
Shajib, M. S. - Islam, S. - Alam, S. - Rashid, R. B. - Afroze, M. - Khan, M. - Datta, B. K. - Nahar, Lutfun - Sarker, S. D. - Rashid, M. A.
GC–MS analysis and pharmacological evaluations of Phoenix sylvestris (Roxb.) seeds provide new insights into the management of oxidative stress and hyperglycemia.
Food Science & Nutrition. Roč. 11, č. 3 (2023), s. 1553-1562. ISSN 2048-7177. E-ISSN 2048-7177
Institutional support: RVO:61389030
Keywords : antihyperglycemic * antioxidant * Arecaceae * gc–ms * Phoenix sylvestris * traditional medicine
OECD category: Agricultural biotechnology and food biotechnology
Impact factor: 3.9, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/fsn3.3196

Phoenix sylvestris Roxb. (Arecaceae) seeds are used in the treatment of diabetes in the traditional system of medicine. The present study evaluated antihyperglycemic and antioxidant activities as well as the total phenolic and flavonoid content of the methanol extract of P. sylvestris seeds (MEPS). The constituents of the extract were identified by GC–MS analysis. MEPS demonstrated strong antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50 = 162.70 ± 14.99 μg) and nitric oxide (NO) (IC50 = 101.56 ± 9.46 μg/ml) free radicals. It also possesses a substantial amount of phenolics and flavonoids. It significantly (p <.05) reduced blood glucose levels in glucose-loaded and alloxan-induced diabetic mice at the doses of 150 and 300 mg/kg b.w., respectively. A total of 46 compounds were detected and identified by gas chromatography–mass spectroscopy (GC–MS) analysis, among which 8-methylisoquinoline N-oxide (32.82%) was predominant. The phytochemical study by GC–MS revealed that the MEPS possesses compounds which could be related to its antidiabetic and antioxidant activities. To recapitulate, P. sylvestris seeds can be a very good option for antidiabetic and antioxidant activity though further studies are still recommended to figure out the responsible phytochemicals and establish their exact mechanism of action.
Permanent Link: https://hdl.handle.net/11104/0345532