0575460 - FZÚ 2024 RIV GB eng J - Journal Article
Harmošová, M. - Vilková, M. - Kello, M. - Smolko, L. - Samoľová, Erika - Šebová, D. - Potočňák, I.
Low-dimensional compounds containing bioactive ligands. XXII. First crystal structure, cytotoxic activity and DNA and HSA binding of a zirconium(IV) complex with 8-hydroxyquinoline-2-carboxylic acid.
Acta Crystallographica Section C-Structural Chemistry. Roč. 79, July (2023), s. 316-323. ISSN 2053-2296. E-ISSN 2053-2296
R&D Projects: GA MŠMT LM2023051
Institutional support: RVO:68378271
Keywords : crystal structure * cytotoxicity * ZrIV complex * 8-hydroxyquinoline-2-carboxylic acid * low-dimensional * bioactive ligand * DNA binding * HSA binding
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 0.7, year: 2023
Method of publishing: Limited access
https://doi.org/10.1107/S2053229623005971

A new zirconium(IV) complex, diaquabis(8-hydroxyquinoline-2-carboxylato-κ3N,O2,O8)zirconium(IV) dimethylformamide disolvate, [Zr(C10H5NO3)2-(H2O)2]·2C3H7NO or [Zr(QCa)2(H2O)2]·2DMF (1) (HQCaH is 8-hydroxyquinoline-2-carboxylic acid and DMF is dimethylformamide), was prepared and characterized by elemental analysis, IR spectroscopy and single-crystal X-ray structure analysis. The cytotoxic properties of 1 and HQCaH were studied in vitro against eight cancer cell lines, and their selectivity was tested on the BJ-5ta noncancerous cell line.
Permanent Link: https://hdl.handle.net/11104/0349400