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New insight into the biocompatibility/toxicity of graphene oxides and their reduced forms on Chlamydomonas reinhardtii
- 1.0575444 - ÚEB 2024 RIV NL eng J - Journal Article
Bytešníková, Z. - Koláčková, M. - Dobešová, M. - Švec, P. - Ridošková, A. - Pekárková, J. - Přibyl, J. - Cápal, Petr - Húska, D. - Adam, V. - Richtera, L.
New insight into the biocompatibility/toxicity of graphene oxides and their reduced forms on Chlamydomonas reinhardtii.
NANOIMPACT. Roč. 31, JUL (2023), č. článku 100468. ISSN 2452-0748. E-ISSN 2452-0748
Institutional support: RVO:61389030
Keywords : Graphene oxide * Reduction * Toxicity * Biocompatibility * Chlamydomonas * Microalgae
OECD category: Biochemistry and molecular biology
Impact factor: 4.9, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.impact.2023.100468
Graphene oxides (GOs) and their reduced forms are often discussed both positively and negatively due to the of information about their chemistry and structure. This study utilized GOs with two sheet sizes that were further reduced by two reducing agents (sodium borohydride and hydrazine) to obtain two different degrees reduction. The synthesized nanomaterials were characterized using scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), elemental analysis (EA), Fourier transform infrared (FTIR) spectroscopy, and Raman spectroscopy (RA) to understand their chemistry and structure. second focus of our investigation included in vitro testing of the biocompatibility/toxicity of these materials model organism, the freshwater microalga Chlamydomonas reinhardtii. The effects were studied on the basis biological endpoints complemented by biomass investigation (FTIR spectroscopy, EA, and atomic absorption spectrometry (AAS)). The results showed that the biocompatibility/toxicity of GOs is dependent on chemistry and structure and that it is impossible to generalize the toxicity of graphene-based nanomaterials.
Permanent Link: https://hdl.handle.net/11104/0345229
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