Obesity, Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms

0575136 - ÚOCHB 2024 RIV CZ eng J - Journal Article
Kuneš, Jaroslav - Hojná, S. - Mráziková, Lucia - Montezano, A. - Touyz, R. M. - Maletínská, Lenka
Obesity, Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms.
Physiological Research. Roč. 72, Suppl. 2 (2023), S73-S90. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA ČR(CZ) GA20-00546S
Institutional support: RVO:61388963
Keywords : obesity * cardiovascular * neurodegeneration * Alzheimer's disease * small vessel disease * oxidative stress * inflammation * gut microbiota
OECD category: Physiology (including cytology)
Impact factor: 2.1, year: 2022
Method of publishing: Open access
https://doi.org/10.33549/physiolres.935109

The worldwide increase in the incidence of obesity and cardiovascular and neurodegenerative diseases, e.g. Alzheimer's disease, is related to many factors, including an unhealthy lifestyle and aging populations. However, the interconnection between these diseases is not entirely clear, and it is unknown whether common mechanisms underlie these conditions. Moreover, there are currently no fully effective therapies for obesity and neurodegeneration. While there has been extensive research in preclinical models addressing these issues, the experimental findings have not been translated to the clinic. Another challenge relates to the time of onset of individual diseases, which may not be easily identified, since there are no specific indicators or biomarkers that define disease onset. Hence knowing when to commence preventive treatment is unclear. This is especially pertinent in neurodegenerative diseases, where the onset of the disease may be subtle and occur decades before the signs and symptoms manifest. In metabolic and cardiovascular disorders, the risk may occur in-utero, in line with the concept of fetal programming. This review provides a brief overview of the link between obesity, cardiovascular and neurodegenerative diseases and discusses potential common mechanisms including the role of the gut microbiome.
Permanent Link: https://hdl.handle.net/11104/0344996