A Current State of Proteomics in Adult and Pediatric Inflammatory Bowel Diseases: A Systematic Search and Review

0574687 - MBÚ 2024 RIV CH eng J - Journal Article
Fabian, O. - Bajer, Lukáš - Drastich, P. - Harant, K. - Sticová, E. - Dasková, N. - Modos, I. - Tichánek, F. - Cahová, M.
A Current State of Proteomics in Adult and Pediatric Inflammatory Bowel Diseases: A Systematic Search and Review.
International Journal of Molecular Sciences. Roč. 24, č. 11 (2023), č. článku 9386. ISSN 1661-6596
R&D Projects: GA MZd(CZ) NU22-06-00269; GA ČR(CZ) GA20-03997S
Institutional support: RVO:61388971
Keywords : Crohn's disease * inflammatory bowel disease * pediatric * proteomics * proteome * ulcerative colitis
OECD category: Microbiology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/1422-0067/24/11/9386

Inflammatory bowel diseases (IBD) are systemic immune-mediated conditions with predilection for the gastrointestinal tract and include Crohn's disease and ulcerative colitis. Despite the advances in the fields of basic and applied research, the etiopathogenesis remains largely unknown. As a result, only one third of the patients achieve endoscopic remission. A substantial portion of the patients also develop severe clinical complications or neoplasia. The need for novel biomarkers that can enhance diagnostic accuracy, more precisely reflect disease activity, and predict a complicated disease course, thus, remains high. Genomic and transcriptomic studies contributed substantially to our understanding of the immunopathological pathways involved in disease initiation and progression. However, eventual genomic alterations do not necessarily translate into the final clinical picture. Proteomics may represent a missing link between the genome, transcriptome, and phenotypical presentation of the disease. Based on the analysis of a large spectrum of proteins in tissues, it seems to be a promising method for the identification of new biomarkers. This systematic search and review summarize the current state of proteomics in human IBD. It comments on the utility of proteomics in research, describes the basic proteomic techniques, and provides an up-to-date overview of available studies in both adult and pediatric IBD.
Permanent Link: https://hdl.handle.net/11104/0345019