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Exopolysaccharide from Lacticaseibacillus rhamnosus induces IgA production in airways and alleviates allergic airway inflammation in mouse model
- 1.0574673 - MBÚ 2024 RIV US eng J - Journal Article
Šrůtková, Dagmar - Kozáková, Hana - Novotná, Tereza - Górska, S. - Hermanová, Petra - Hudcovic, Tomáš - Švábová, Tereza - Šinkora, Marek - Schwarzer, Martin
Exopolysaccharide from Lacticaseibacillus rhamnosus induces IgA production in airways and alleviates allergic airway inflammation in mouse model.
European Journal of Immunology. Roč. 53, č. 7 (2023), č. článku 2250135. ISSN 0014-2980. E-ISSN 1521-4141
R&D Projects: GA ČR GA19-02261S; GA MŠMT(CZ) 8JPL19046
Grant - others:European Molecular Biology Organisation Heidelberg 4139 EMBO
Institutional support: RVO:61388971
Keywords : Allergic airway inflammation * Exopolysaccharide * IgA antibody * Immunomodulation * Lacticaseibacillus
OECD category: Immunology
Impact factor: 5.4, year: 2022
Method of publishing: Limited access
https://onlinelibrary.wiley.com/doi/10.1002/eji.202250135
The currently observed high prevalence of allergic diseases has been associated with changes in microbial exposure in industrialized countries. Defined bacterial components represent a new strategy for modulating the allergic immune response. We show that intranasal administration of exopolysaccharide (EPS) isolated from Lacticaseibacillus (L.) rhamnosus LOCK900 induces TGF-beta 1, IgA, and regulatory FoxP3(+) T-cells in the lungs of naive mice. Using the ovalbumin mouse model, we demonstrate that intranasal administration of EPS downregulates the development of allergic airway inflammation and the Th2 cytokine response in sensitized individuals. At the same time, EPS treatment of sensitized mice, similar to EPS-induced responses in naive mice, significantly increased the level of total, OVA-specific, and also bacteria-specific IgA in bronchoalveolar lavage and the number of IgA-producing B-cells in the lung tissue of these mice. Thus, EPS derived from L. rhamnosus LOCK900 can be considered a safe candidate for preventing the development of allergic symptoms in the lungs of sensitized individuals upon exposure to an allergen.
Permanent Link: https://hdl.handle.net/11104/0345878
Number of the records: 1