G-quadruplex ligands as potent regulators of lysosomes

0574518 - BFÚ 2024 RIV GB eng J - Journal Article
Ferret, L. - Alvarez-Valadez, K. - Riviere, J. - Muller, A. - Bohalova, Natalia - Yu, L. - Guittat, L. - Brázda, Václav - Kroemer, G. - Mergny, Jean-Louis - Djavaheri-Mergny, M.
G-quadruplex ligands as potent regulators of lysosomes.
Autophagy. Roč. 19, č. 7 (2023), s. 1901-1915. ISSN 1554-8627. E-ISSN 1554-8635
R&D Projects: GA MŠMT EF15_003/0000477; GA ČR(CZ) GA22-21903S
Institutional support: RVO:68081707
Keywords : Autophagy * guanine-quadruplex * lysosome membrane permeabilization * tfeb * transcriptional regulation
OECD category: Cell biology
Impact factor: 13.3, year: 2022
Method of publishing: Limited access
https://www.tandfonline.com/doi/full/10.1080/15548627.2023.2170071

Guanine-quadruplex structures (G4) are unusual nucleic acid conformations formed by guanine-rich DNA and RNA sequences and known to control gene expression mechanisms, from transcription to protein synthesis. So far, a number of molecules that recognize G4 have been developed for potential therapeutic applications in human pathologies, including cancer and infectious diseases. These molecules are called G4 ligands. When the biological effects of G4 ligands are studied, the analysis is often limited to nucleic acid targets. However, recent evidence indicates that G4 ligands may target other cellular components and compartments such as lysosomes and mitochondria. Here, we summarize our current knowledge of the regulation of lysosome by G4 ligands, underlying their potential functional impact on lysosome biology and autophagic flux, as well as on the transcriptional regulation of lysosomal genes. We outline the consequences of these effects on cell fate decisions and we systematically analyzed G4-prone sequences within the promoter of 435 lysosome-related genes. Finally, we propose some hypotheses about the mechanisms involved in the regulation of lysosomes by G4 ligands.
Permanent Link: https://hdl.handle.net/11104/0350465