Cu(III) Trifluoromethyl Complexes with 1,3-Diketonate Ligands and Their Versatile Reactivity in C–H Trifluoromethylation

0573761 - ÚOCHB 2024 RIV DE eng J - Journal Article
Motornov, Vladimir - Klepetářová, Blanka - Beier, Petr
Cu(III) Trifluoromethyl Complexes with 1,3-Diketonate Ligands and Their Versatile Reactivity in C–H Trifluoromethylation.
Advanced Synthesis & Catalysis. Roč. 365, č. 17 (2023), s. 2858-2864. ISSN 1615-4150. E-ISSN 1615-4169
R&D Projects: GA ČR(CZ) GA23-04659S
Institutional support: RVO:61388963
Keywords : copper * high-valent copper * trifluoromethylation * C-H activation * 1,3-diketonates
OECD category: Organic chemistry
Impact factor: 5.4, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/adsc.202300695

High-valent Cu(III) trifluoromethyl complexes with 1,3-diketonates as bidentate oxygen donor ligands LCuIII(CF3)2 were prepared for the first time and fully characterized, including by X-ray crystallography. These complexes are bench stable and soluble in most organic solvents. Promising reactivity of Cu(III) trifluoromethyl diketonates in radical and radical–polar crossover trifluoromethylation reactions was demonstrated. Direct C–H trifluoromethylation of electron-rich arenes and indoles using Cu(III) trifluoromethyl diketonates under blue light irradiation is described. Azolo- and oxy-trifluoromethylation of terminal alkynes and S-trifluoromethylation of aromatic thiol can be achieved using LCuIII(CF3)2 in mild conditions.
Permanent Link: https://hdl.handle.net/11104/0344130


Research data: CCDC