Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice

0573086 - MBÚ 2024 RIV US eng J - Journal Article
Schwarzer, Martin - Gautam, Umesh Kumar - Makki, K. - Lambert, A. - Brabec, Tomáš - Joly, A. - Šrůtková, Dagmar - Poinsot, P. - Novotná, Tereza - Geoffroy, S. - Courtin, P. - Hermanová, Petra - Matos, R. C. - Landry, J. J. M. - Gérard, C. - Bulteau, A. - Hudcovic, Tomáš - Kozáková, Hana - Filipp, Dominik - Chapot-Chartier, M. - Šinkora, Marek - Peretti, N. - Boneca, I. G. - Chamaillard, M. - Vidal, H. - De Vadder, F. - Leulier, F.
Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice.
Science. Roč. 379, č. 6634 SI (2023), s. 826-833. ISSN 0036-8075. E-ISSN 1095-9203
R&D Projects: GA ČR(CZ) GM21-19640M; GA ČR(CZ) GJ18-07015Y; GA ČR GA20-30350S
EU Projects: European Commission(DE) 4139 EMBO
Grant - others:AV ČR(CZ) Fellowship J. E. Purkyně
Program: Fellowship J. E. Purkyně
Institutional support: RVO:61388971 ; RVO:68378050
Keywords : intestinal microbiota * LpWJLsustains * NOD2 * IGF-1
OECD category: Microbiology; Immunology (UMG-J)
Impact factor: 56.9, year: 2022
Method of publishing: Open access
https://www.science.org/doi/10.1126/science.ade9767

The intestinal microbiota is known to influence postnatal growth. We previously found that a strain of Lactiplantibacillus plantarum (strain LpWJL) buffers the adverse effects of chronic undernutrition on the growth of juvenile germ-free mice. Here, we report that LpWJLsustains the postnatal growth of malnourished conventional animals and supports both insulin-like growth factor-1 (IGF-1) and insulin production and activity. We have identified cell walls isolated from LpWJL, as well as muramyl dipeptide and mifamurtide, as sufficient cues to stimulate animal growth despite undernutrition. Further, we found that NOD2 is necessary in intestinal epithelial cells for LpWJL-mediated IGF-1 production and for postnatal growth promotion in malnourished conventional animals. These findings indicate that, coupled with renutrition, bacteria cell walls or purified NOD2 ligands have the potential to alleviate stunting.
Permanent Link: https://hdl.handle.net/11104/0343688