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Synthesis and cytotoxicity of fluorinated mannosamines
- 1.0572648 - ÚCHP 2024 CZ eng K - Conference Paper (Czech conference)
Krčil, Aleš
Synthesis and cytotoxicity of fluorinated mannosamines.
Proceedings of Abstracts. Prague: Institute of Chemical Process Fundamentals of the CAS, v. v. i., 2023 - (Bendová, M.; Wagner, Z.; Windell, L.), s. 18-19. ISBN 978-80-86186-29-0.
[Bažant postraguate conference 2023. Prague (CZ), 31.05.2023-01.06.2023]
Institutional support: RVO:67985858
Keywords : synthesis * cytotoxicity * fluorinated mannosamines
OECD category: Organic chemistry
The aim of the project is to synthesise mono-, di- and trifluoroanalogs of N-acetylmannosamines. The cytotoxicity of the final products towards selected cancer cells will be determined. The key intermediates are the corresponding multiply fluorinated mannosazidethioglycosides prepared from deoxyfluorinated 1,6-anhydro-2-azidoβ-D-hexopyranose precursors by ring-opening reactions with phenyltrimethylsilyl sulfide.
Permanent Link: https://hdl.handle.net/11104/0343248
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Number of the records: 1