Identification of GC-rich LAT genes in birds

0572429 - ÚMG 2024 RIV US eng J - Journal Article
Janušová, Šárka - Krchlíková, Veronika - Hron, Tomáš - Elleder, Daniel - Štěpánek, Ondřej
Identification of GC-rich LAT genes in birds.
PLoS ONE. Roč. 18, č. 4 (2023), č. článku e0283431. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:68378050
Keywords : T-CELL-RECEPTOR * ACTIVATION * LINKER * PHOSPHORYLATION * MUTATION * PROTEINS
OECD category: Biochemistry and molecular biology
Impact factor: 3.7, year: 2022
Method of publishing: Open access
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283431

Linker for activation of T cells (LAT) plays a key role in T-cell antigenic signaling in mammals. Accordingly, LAT orthologues were identified in the majority of vertebrates. However, LAT orthologues were not identified in most birds. In this study, we show that LAT gene is present in genomes of multiple extant birds. It was not properly assembled previously because of its GC-rich content. LAT expression is enriched in lymphoid organs in chicken. The analysis of the coding sequences revealed a strong conservation of key signaling motifs in LAT between chicken and human. Overall, our data indicate that mammalian and avian LAT genes are functional homologues with a common role in T-cell signaling.
Permanent Link: https://hdl.handle.net/11104/0343162