Energy partitioning in multicomponent nanoscintillators for enhanced localized radiotherapy

0572337 - FZÚ 2024 RIV US eng J - Journal Article
Secchi, V. - Cova, F. - Villa, Irene - Babin, Vladimir - Nikl, Martin - Campione, M. - Monguzzi, A.
Energy partitioning in multicomponent nanoscintillators for enhanced localized radiotherapy.
ACS Applied Materials and Interfaces. Roč. 15, č. 20 (2023), s. 24693-24700. ISSN 1944-8244. E-ISSN 1944-8252
R&D Projects: GA MŠMT(CZ) EF16_019/0000760
EU Projects: European Commission(XE) 101003405 - HANSOME
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : radiotherapy * scintillators * energy transfer * singlet oxygen * nanomaterials
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 9.5, year: 2022
Method of publishing: Open access

Multicomponent nanomaterials consisting of dense scintillating particles functionalized by or embedding optically active conjugated photosensitizers (PSs) for cytotoxic reactive oxygen species (ROS) have been proposed in the last decade as coadjuvant agents for radiotherapy of cancer. We investigate this mechanism in a series of PS-functionalized scintillating nanotubes where the non-radiative energy transfer yield has been tuned by control of the intermolecular distance between the nanotube and the conjugated system. The obtained results indicate that non-radiative energy transfer has a negligible effect on the ROS sensitization efficiency, thus opening the way to the development of different architectures for breakthrough radiotherapy coadjutants to be tested in clinics.
Permanent Link: https://hdl.handle.net/11104/0343087