Helminthic host defense peptides: using the parasite to defend the host

0572127 - BC 2024 RIV NL eng J - Journal Article
Mladineo, Ivona - Roncevic, T. - Gerdol, M. - Tossi, A.
Helminthic host defense peptides: using the parasite to defend the host.
Trends in Parasitology. Roč. 39, č. 5 (2023), s. 345-357. ISSN 1471-4922. E-ISSN 1471-5007
EU Projects: European Commission 101084204 - Cure4Aqua
Institutional support: RVO:60077344
Keywords : PlusC.-ELEGANS * ANTIMICROBIAL * PEPTIDES * NEMATODES * ASABF * EVOLUTION * CECROPINS * FAMILY
OECD category: Fishery
Impact factor: 9.6, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S1471492223000338?via%3Dihub

Parasitic helminths are destined to share niches with a variety of microbiota that inevitably influence their interaction with the host. To modulate the microbiome for their benefit and defend against pathogenic isolates, helminths have devel-oped host defense peptides (HDPs) and proteins as integral elements of their im-munity. These often exert a relatively nonspecific membranolytic activity toward bacteria, sometimes with limited or no toxicity toward host cells. With a few ex-ceptions, such as nematode cecropin-like peptides and antibacterial factors (ABFs), helminthic HDPs are largely underexplored. This review scrutinizes cur-rent knowledge on the repertoire of such peptides in helminths and promotes their research as potential leads for an anti-infective solution to the burgeoning problem of antibiotic resistance.
Permanent Link: https://hdl.handle.net/11104/0345755