Autonomous capillary electrophoresis processing and analysis of dried blood spots for high-throughput determination of uric acid

0572094 - ÚIACH 2024 RIV NL eng J - Journal Article
Moravčík, Ondrej - Dvořák, Miloš - Kubáň, Pavel
Autonomous capillary electrophoresis processing and analysis of dried blood spots for high-throughput determination of uric acid.
Analytica Chimica Acta. Roč. 1267, AUG (2023), č. článku 341390. ISSN 0003-2670. E-ISSN 1873-4324
R&D Projects: GA ČR(CZ) GA23-05972S
Institutional support: RVO:68081715
Keywords : dried blood spots * capillary electrophoresis * automated analysis
OECD category: Analytical chemistry
Impact factor: 6.2, year: 2022
Method of publishing: Limited access

A new set-up for high-throughput and fully autonomous analyses of DBS samples was presented. A single off-the-shelf CE instrument served for executing all tasks of the analytical protocol. A fused silica capillary of the CE instrument was first used for accurate and precise liquid handling, DBS elution, and DBS eluate homogenization and subsequently, the same capillary (and the same CE instrument) was also used for selective determination of uric acid in the resulting eluate.
Permanent Link: https://hdl.handle.net/11104/0342922