The giant diploid faba genome unlocks variation in a global protein crop

0571900 - ÚEB 2024 RIV DE eng J - Journal Article
Jayakodi, M. - Golicz, A. A. - Kreplak, J. - Fechete, L. I. - Angra, D. - Bednář, P. - Bornhofen, E. - Zhang, H. - Boussageon, R. - Kaur, S. - Cheung, K. - Čížková, Jana - Gundlach, H. - Hallab, A. - Imbert, E. - Keeble-Gagnère, G. - Koblížková, Andrea - Kobrlová, L. - Krejčí, P. - Mouritzen, T. W. - Neumann, Pavel - Nadzieja, M. - Nielsen, L. K. - Novák, Petr - Orabi, J. - Padmarasu, S. - Robertson-Shersby-Harvie, T. - Robledillo, Laura Avila - Schiemann, A. - Tanskanen, J. - Törönen, P. - Warsame, A. O. - Wittenberg, A. H.J. - Himmelbach, A. - Aubert, G. - Courty, P.-E. - Doležel, Jaroslav - Holm, L. U. - Janss, L. L. - Khazaei, H. - Macas, Jiří - Mascher, M. - Smýkal, P. - Snowdon, R. J. - Stein, N. - Stoddard, F. L. - Stougaard, J. - Tayeh, N. - Torres, A. M. - Usadel, C. - Schubert, I. - O’Sullivan, D. - Schulman, A. H. - Andersen, S.U.
The giant diploid faba genome unlocks variation in a global protein crop.
Nature. Roč. 615, č. 7953 (2023), s. 652-659. ISSN 0028-0836. E-ISSN 1476-4687
R&D Projects: GA ČR(CZ) GA20-24252S; GA MŠMT(CZ) LM2018131
Institutional support: RVO:61389030 ; RVO:60077344
Keywords : NUCLEAR-DNA CONTENT * SEQUENCE * PROGRAM
OECD category: Genetics and heredity (medical genetics to be 3); Genetics and heredity (medical genetics to be 3) (BC-A)
Impact factor: 64.8, year: 2022
Method of publishing: Open access
https://doi.org/10.1038/s41586-023-05791-5

Increasing the proportion of locally produced plant protein in currently meat-rich diets could substantially reduce greenhouse gas emissions and loss of biodiversity1. However, plant protein production is hampered by the lack of a cool-season legume equivalent to soybean in agronomic value2. Faba bean (Vicia faba L.) has a high yield potential and is well suited for cultivation in temperate regions, but genomic resources are scarce. Here, we report a high-quality chromosome-scale assembly of the faba bean genome and show that it has expanded to a massive 13 Gb in size through an imbalance between the rates of amplification and elimination of retrotransposons and satellite repeats. Genes and recombination events are evenly dispersed across chromosomes and the gene space is remarkably compact considering the genome size, although with substantial copy number variation driven by tandem duplication. Demonstrating practical application of the genome sequence, we develop a targeted genotyping assay and use high-resolution genome-wide association analysis to dissect the genetic basis of seed size and hilum colour. The resources presented constitute a genomics-based breeding platform for faba bean, enabling breeders and geneticists to accelerate the improvement of sustainable protein production across the Mediterranean, subtropical and northern temperate agroecological zones.
Permanent Link: https://hdl.handle.net/11104/0342790