Interaction between nanomaterials and the innate immune system across evolution

0571675 - MBÚ 2024 RIV US eng J - Journal Article
Boraschi, D. - Canesi, L. - Drobne, D. - Kemmerling, B. - Pinsino, A. - Procházková, Petra
Interaction between nanomaterials and the innate immune system across evolution.
Biological Reviews. Roč. 98, č. 3 (2023), s. 747-774. ISSN 1464-7931. E-ISSN 1469-185X
R&D Projects: GA MŠMT(CZ) LO1509
EU Projects: European Commission(XE) 671881 - PANDORA
Institutional support: RVO:61388971
Keywords : innate immunity * Toll-like receptors * phagocytes * plants * invertebrates * human * in vivo * in vitro
OECD category: Immunology
Impact factor: 10, year: 2022
Method of publishing: Open access
https://onlinelibrary.wiley.com/doi/10.1111/brv.12928

Interaction of engineered nanomaterials (ENMs) with the immune system mainly occurs with cells and molecules of innate immunity, which are present in interface tissues of living organisms. Immuno-nanotoxicological studies aim at understanding if and when such interaction is inconsequential or may cause irreparable damage. Since innate immunity is the first line of immune reactivity towards exogenous agents and is highly conserved throughout evolution, this review focuses on the major effector cells of innate immunity, the phagocytes, and their major sensing receptors, Toll-like receptors (TLRs), for assessing the modes of successful versus pathological interaction between ENMs and host defences. By comparing the phagocyte- and TLR-dependent responses to ENMs in plants, molluscs, annelids, crustaceans, echinoderms and mammals, we aim to highlight common recognition and elimination mechanisms and the general sufficiency of innate immunity for maintaining tissue integrity and homeostasis.
Permanent Link: https://hdl.handle.net/11104/0343234