Combining neuropsychological assessment with neuroimaging to distinguish early-stage Alzheimer's disease from frontotemporal lobar degeneration in non-western tonal native Language-speaking individuals living in Taiwan: A case series

0571617 - FZÚ 2024 RIV CH eng J - Journal Article
Kuo, C.Y. - Tseng, H.-Y. - Stachiv, Ivo - Tsai, C.-H. - Lai, Y.-Ch. - Nikolai, T.
Combining neuropsychological assessment with neuroimaging to distinguish early-stage Alzheimer's disease from frontotemporal lobar degeneration in non-western tonal native Language-speaking individuals living in Taiwan: A case series.
Journal of Clinical Medicine. Roč. 12, č. 4 (2023), č. článku 1322. E-ISSN 2077-0383
R&D Projects: GA ČR(CZ) GC21-12994J; GA MŠMT(CZ) EF16_019/0000760
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : Alzheimer's disease * frontotemporal lobar degeneration * frontotemporal dementia * neuropsychological assessment * cognitive impairment * bvFTD * PPA * neuroimaging
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 3.9, year: 2022
Method of publishing: Open access

Neuropsychological tests (NPTs), which are routinely used in clinical practice for assessment of dementia, are also considered to be essential for differential diagnosis of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD), especially the behavioral variants of frontotemporal dementia (bvFTD) and primary progressive aphasia (PPA) at their initial clinical presentations. However, the heterogeneous features of these diseases, which have many overlapping signs, make differentiation between AD and FTLD highly challenging. Moreover, NPTs were primarily developed in Western countries and for native speakers of non-tonal languages. Hence, there is an ongoing dispute over the validity and reliability of these tests in culturally different and typologically diverse language populations. The purpose of this case series was to examine which of the NPTs adjusted for Taiwanese society may be used to distinguish these two diseases.
Permanent Link: https://hdl.handle.net/11104/0350598