Insect Chronobiology

0571397 - BC 2024 RIV SG eng M - Monography Chapter
Doležel, David
Molecular Mechanism of the Circadian Clock.
Insect Chronobiology. Singapore: Springer, 2023 - (Numata, H.; Tomioka, K.), s. 49-84. ISBN 978-981-99-0725-0
Institutional support: RVO:60077344
Keywords : cryptochrome * evolution * negative feedback
OECD category: Developmental biology
https://link.springer.com/chapter/10.1007/978-981-99-0726-7_4

Nearly all organisms possess a circadian clock, a genetically determined device that generates endogenous oscillations with a period of approximately 24 h. From a molecular perspective, the circadian clock relies on negative transcription-translation feedback loops. In insects, the molecular and genetic basis of the circadian clock machinery has been revealed by the remarkable genetic tools available to the fruit fly Drosophila melanogaster. However, the dawn of reverse genetics methods applicable to nonmodel species has led to recent significant advances in our understanding of the circadian clock beyond Drosophila. To illustrate the molecular mechanism behind the insect circadian clock, the first section focuses primarily on Drosophila melanogaster as the best established and most detailed insect model. Conserved components of the insect clocks are then identified at the genetic level, and lineage-specific idiosyncrasies and variations in setup are highlighted and further discussed. Functional evidence from non-Drosophila insects is reviewed, and the main descriptive data from molecular biology are presented in an evolutionary context and briefly summarized.
Permanent Link: https://hdl.handle.net/11104/0352467