Hypertension in Primary Aldosteronism Is Initiated by Salt-Induced Increases in Vascular Resistance With Reductions in Cardiac Output

0571379 - FGÚ 2024 RIV US eng J - Journal Article
Kurtz, T. W. - Morris Jr., R. C. - Pravenec, Michal - Lujan, H. L. - DiCarlo, S. E.
Hypertension in Primary Aldosteronism Is Initiated by Salt-Induced Increases in Vascular Resistance With Reductions in Cardiac Output.
Hypertension. Roč. 80, č. 5 (2023), s. 1077-1091. ISSN 0194-911X. E-ISSN 1524-4563
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA MŠMT(CZ) LUAUS23095
Institutional support: RVO:67985823
Keywords : sodium * salts * hypertension * blood pressure * aldosterone
OECD category: Cardiac and Cardiovascular systems
Impact factor: 8.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1161/HYPERTENSIONAHA.123.20953

Results:In vehicle-treated control rats, switching from a low-salt diet to a high-salt diet initiated modest increases in mean arterial pressure by increasing SVR while simultaneously decreasing heart rate and CO. In aldosterone-treated rats compared with control rats, switching from a low-salt diet to a high-salt diet initiated significantly greater increases in mean arterial pressure and SVR and significantly greater decreases in heart rate and CO.
Conclusions:Aldosterone promoted salt sensitivity and initiation of salt-dependent hypertension by amplifying salt-induced increases in SVR while decreasing CO. Increases in CO are not required for the initiation or maintenance of hypertension. These findings challenge the traditional view of the hemodynamic mechanisms that cause hypertension in primary aldosteronism.

Permanent Link: https://hdl.handle.net/11104/0342620