Astrocytic TRPV4 Channels and Their Role in Brain Ischemia

0571198 - ÚEM 2024 RIV CH eng J - Journal Article
Turečková, Jana - Heřmanová, Zuzana - Marchetti, Valeria - Anděrová, Miroslava
Astrocytic TRPV4 Channels and Their Role in Brain Ischemia.
International Journal of Molecular Sciences. Roč. 24, č. 8 (2023), č. článku 7101. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) LX22NPO5107; GA ČR(CZ) GA20-05770S
Institutional support: RVO:68378041
Keywords : TRPV4 * Ca2+ signaling * ischemia * glia * astrocytes
OECD category: Neurosciences (including psychophysiology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/1422-0067/24/8/7101

Transient receptor potential cation channels subfamily V member 4 (TRPV4) are non-selective cation channels expressed in different cell types of the central nervous system. These channels can be activated by diverse physical and chemical stimuli, including heat and mechanical stress. In astrocytes, they are involved in the modulation of neuronal excitability, control of blood flow, and brain edema formation. All these processes are significantly impaired in cerebral ischemia due to insufficient blood supply to the tissue, resulting in energy depletion, ionic disbalance, and excitotoxicity. The polymodal cation channel TRPV4, which mediates Ca2+ influx into the cell because of activation by various stimuli, is one of the potential therapeutic targets in the treatment of cerebral ischemia. However, its expression and function vary significantly between brain cell types, and therefore, the effect of its modulation in healthy tissue and pathology needs to be carefully studied and evaluated. In this review, we provide a summary of available information on TRPV4 channels and their expression in healthy and injured neural cells, with a particular focus on their role in ischemic brain injury.
Permanent Link: https://hdl.handle.net/11104/0342517