Comparison of chemical and electrochemical approaches to abacavir oxidative stability testing

0570736 - FZÚ 2024 RIV CH eng J - Journal Article
Pražáková, L. - Fischer, J. - Taylor, Andrew - Kubíčková, A.
Comparison of chemical and electrochemical approaches to abacavir oxidative stability testing.
Sensors. Roč. 23, č. 5 (2023), č. článku 2776. E-ISSN 1424-8220
R&D Projects: GA ČR(CZ) GA23-05688S
Institutional support: RVO:68378271
Keywords : degradation of pharmaceuticals * abacavir * oxidation * boron-doped diamond electrode * platinum electrode
OECD category: Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Impact factor: 3.9, year: 2022
Method of publishing: Open access

A novel electrochemical approach using two different electrode materials, platinum and boron-doped diamond (BDD), was employed to study the oxidative stability of the drug abacavir. Abacavir samples were subjected to oxidation and subsequently analysed using chromatography with mass detection. The type and amount of degradation products were evaluated, and results were compared with traditional chemical oxidation using 3% hydrogen peroxide. The effect of pH on the rate of degradation and the formation of degradation products were also investigated. In general, both approaches led to the same two degradation products, identified using mass spectrometry, and characterised by 319.20 and m/z 247.19. Similar results were obtained on a large-surface platinum electrode at a potential of +1.15 V and a BDD disc electrode at +4.0 V.
Permanent Link: https://hdl.handle.net/11104/0342073