Intermittent F-actin perturbations by magnetic fields inhibit breast cancer metastasis

0570700 - FZÚ 2024 RIV US eng J - Journal Article
Ji, X. - Tian, X. - Feng, S. - Zhang, L. - Wang, J. - Guo, R. - Zhu, Y. - Yu, X. - Zhang, Y. - Du, H. - Zablotskii, Vitalii - Zhang, X.
Intermittent F-actin perturbations by magnetic fields inhibit breast cancer metastasis.
Research. Roč. 6, Mar (2023), č. článku 0080. ISSN 2096-5168. E-ISSN 2639-5274
R&D Projects: GA MŠMT(CZ) EF16_019/0000760
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : F-actin * magnetic field * electric field * cancer metastasis
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 11, year: 2022
Method of publishing: Open access

F-actin (filamentous actin) has been shown to be sensitive to mechanical stimuli and play critical roles in cell attachment, migration, and cancer metastasis, but there are very limited ways to perturb F-actin dynamics with low cell toxicity. Magnetic field is a noninvasive and reversible physical tool that can easily penetrate cells and human bodies. Here, we show that 0.1/0.4-T 4.2-Hz moderate-intensity low-frequency rotating magnetic field-induced electric field could directly decrease F-actin formation in vitro and in vivo, which results in decreased breast cancer cell migration, invasion, and attachment. Moreover, low- frequency rotating magnetic fields generated significantly different effects on F-actin in breast cancer vs. noncancerous cells, including F-actin number and their recovery after magnetic field retrieval.
Permanent Link: https://hdl.handle.net/11104/0342024