Helicenes: Synthesis, Properties, and Applications

0570507 - ÚOCHB 2023 RIV DE eng M - Monography Chapter
Starý, Ivo - Stará, Irena G.
Synthesis of Helicenes by [2 + 2 + 2] Cycloisomerization of Alkynes and Related Systems.
Helicenes: Synthesis, Properties, and Applications. Weinheim: Wiley, 2022 - (Crassous, J.; Stará, I.; Starý, I.), s. 53-101. ISBN 978-3-527-34810-7
EU Projects: European Commission(XE) 859752 - HEL4CHIROLED
Institutional support: RVO:61388963
Keywords : helicenes * heterohelicenes * enantioselective synthesis * diastereoselective synthesis * [2+2+2] cycloisomerization
OECD category: Organic chemistry
https://doi.org/10.1002/9783527829415.ch2

The results discussed in this chapter show that the constant development of intra/intermolecular transition-metal-catalyzed [2+2+2] cycloisomerization of pi-electron systems as a versatile synthetic methodology for the preparation of helicene derivatives has made them available for their intended applications. It presents several advantages over other methods used for the synthesis of helicenes in terms of functional group tolerance, structural motif variability, regio- and stereoselectivity, atom economy, scale-up and others. It constitutes an alternative to the traditional photocyclodehydrogenation methodology and, in some respects, surpasses it.
Permanent Link: https://hdl.handle.net/11104/0341804