Structurally unique salts of cyamemazine and their pharmaceutical implications

0570385 - FZÚ 2024 RIV US eng J - Journal Article
Ramesh, S. - Skořepová, Eliška - Eigner, Václav - Paingad, Vaisakh Chelod - Zvoníček, V. - Kužel, Petr - Šoóš, M.
Structurally unique salts of cyamemazine and their pharmaceutical implications.
Crystal Growth & Design. Roč. 23, č. 1 (2023), s. 168-179. ISSN 1528-7483. E-ISSN 1528-7505
R&D Projects: GA MŠMT LM2018110; GA MŠMT(CZ) EF16_019/0000760
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : crystal structure * dissolution * molecular interactions * molecules * salts
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 3.8, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acs.cgd.2c00847

The aim of this study was to prepare new crystalline salts of cyamemazine, an antipsychotic drug, with dicarboxylic acids, and compare their thermal stabilities, dissolution properties, and structural features. Among the eight acids investigated, we report novel salts with four acids, namely, L-malic, malonic, succinic, and fumaric acids. The study was extended to include the already known maleate and marketed L-tartrate salts as well. To the best of our knowledge, this is the first-ever study of the solid-state landscape of cyamemazine and report of its crystal structure.
Permanent Link: https://hdl.handle.net/11104/0341700