Protein adsorption by nanomechanical mass spectrometry: Beyond the real-time molecular weighting

0569726 - FZÚ 2024 RIV CH eng J - Journal Article
Stachiv, Ivo - Kuo, C.Y. - Li, Wei
Protein adsorption by nanomechanical mass spectrometry: Beyond the real-time molecular weighting.
Frontiers in molecular biosciences. Roč. 9, Jan (2023), č. článku 1058441. E-ISSN 2296-889X
R&D Projects: GA ČR(CZ) GC21-12994J; GA MŠMT(CZ) EF16_019/0000760
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : protein adsorption * molecule mechanical properties * molecular weight * protein detection * mass spectrometry * mass sensing
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 5, year: 2022
Method of publishing: Open access

During past decades, enormous progress in understanding the mechanisms of the intermolecular interactions between the protein and surface at the single-molecule level has been achieved. These advances could only be possible by the ongoing development of highly sophisticated experimental methods such as atomic force microscopy, optical microscopy, surface plasmon resonance, ellipsometry, quartz crystal microbalance, conventional mass spectrometry, and, more recently, the nanomechanical systems. Here, we highlight the main findings of recent studies on the label-free single-molecule (protein) detection by nanomechanical systems including those focusing on the protein adsorption on various substrate surfaces.
Permanent Link: https://hdl.handle.net/11104/0350599