Serum matrix metalloproteinase-9 (MMP-9) as a biomarker in paediatric and adult tick-borne encephalitis patients

0569304 - BC 2024 RIV NL eng J - Journal Article
Fořtová, A. - Hönig, Václav - Salát, Jiří - Palus, Martin - Pychova, M. - Krbková, L. - Barkhash, A. - Kříha, M.F. - Chrdle, A. - Lipoldová, Marie - Růžek, Daniel
Serum matrix metalloproteinase-9 (MMP-9) as a biomarker in paediatric and adult tick-borne encephalitis patients.
Virus Research. Roč. 324, JAN (2023), č. článku 199020. ISSN 0168-1702. E-ISSN 1872-7492
R&D Projects: GA ČR(CZ) GA20-14325S; GA ČR(CZ) GA20-30500S; GA MZd NV19-05-00457
Institutional support: RVO:60077344 ; RVO:68378050
Keywords : Tick-borne encephalitis * Neuroinfection * Matrix matalloproteinase * Cerebrospinal fluid
OECD category: Virology
Impact factor: 5, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0168170222003495?via%3Dihub

Matrix metalloproteinases (MMPs) play an important role in central nervous system infections. We analysed the levels of 8 different MMPs in the cerebrospinal fluid (CSF) of 89 adult patients infected with tick-borne encephalitis (TBE) virus and compared them with the levels in a control group. MMP-9 was the only MMP that showed significantly increased CSF levels in TBE patients. Serum MMP-9 levels were subsequently measured in 101 adult TBE patients at various time points during the neurological phase of TBE and at follow-up. In addition, serum MMP-9 was analysed in 37 paediatric TBE patients. Compared with control levels, both paediatric and adult TBE patients had significantly elevated serum MMP-9 levels. In most adult patients, serum MMP-9 levels peaked at hospital admission, with higher serum MMP-9 levels observed in patients with encephalitis than in patients with meningitis. Elevated serum MMP-9 levels were observed throughout hospitalisation but decreased to normal levels at follow-up. Serum MMP-9 levels correlated with clinical course, especially in patients heterozygous for the single-nucleotide polymorphism rs17576 (A/G, Gln279Arg) in the MMP9 gene. The results highlight the importance of MMP-9 in the pathogenesis of TBE and suggest that serum MMP-9 may serve as a promising bioindicator of TBE in both paediatric and adult TBE patients.
Permanent Link: https://hdl.handle.net/11104/0344192