Annual Reports in Medicinal Chemistry

0569216 - BC 2023 RIV US eng M - Monography Chapter
Růžek, Daniel
Animal models of tick-borne encephalitis for preclinical antiviral research.
Annual Reports in Medicinal Chemistry. Vol. 58. Cambridge: Elsevier, 2022 - (Neidle, S.), s. 243-256. First edition. ISBN 978-0-323-98893-3
Institutional support: RVO:60077344
Keywords : Animal models * Antivirals * Preclinical testing * Tick-borne encephalitis
OECD category: Parasitology
https://www.sciencedirect.com/science/article/abs/pii/S0065774322000021?pes=vor

Tick-borne encephalitis (TBE), a central nervous system infection caused by the TBE virus (TBEV), is a public health concern in large, forested areas of Europe and Asia. The disease can manifest as a mild, febrile, flu-like illness, but it can also progress to meningitis, encephalitis, or meningoencephalitis. Myelitis and spinal paralysis may also occur. To date, there is no specific drug approved for the treatment of TBE. An essential prerequisite for the development of new specific therapies for TBE is the availability of suitable animal models for TBE. There are several animal models for TBE that include laboratory mice, rats, and nonhuman primates. None of these existing models is ideal for recapitulating all aspects of TBE in humans. Nevertheless, they are useful for studying different aspects of TBE pathogenesis and for testing and developing new therapeutic countermeasures.
Permanent Link: https://hdl.handle.net/11104/0340598