Neurogenesis as a Tool for Spinal Cord Injury

0568846 - ÚEM 2023 RIV CH eng J - Journal Article
Havelíková, Kateřina - Smejkalová, Barbora - Jendelová, Pavla
Neurogenesis as a Tool for Spinal Cord Injury.
International Journal of Molecular Sciences. Roč. 23, č. 7 (2022), č. článku 3728. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA19-10365S; GA MŠMT(CZ) EF15_003/0000419
Institutional support: RVO:68378041
Keywords : neurogenesis * spinal cord injury * ependymal stem cells * astrocytes * reprogramming * spinal canal * physical factors * valproic acid * growth factors * neuroinflammation
OECD category: Neurosciences (including psychophysiology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/1422-0067/23/7/3728

Spinal cord injury is a devastating medical condition with no effective treatment. One approach to SCI treatment may be provided by stem cells (SCs). Studies have mainly focused on the transplantation of exogenous SCs, but the induction of endogenous SCs has also been considered as an alternative. While the differentiation potential of neural stem cells in the brain neurogenic regions has been known for decades, there are ongoing debates regarding the multipotent differentiation potential of the ependymal cells of the central canal in the spinal cord (SCECs). Following spinal cord insult, SCECs start to proliferate and differentiate mostly into astrocytes and partly into oligodendrocytes, but not into neurons. However, there are several approaches concerning how to increase neurogenesis in the injured spinal cord, which are discussed in this review. The potential treatment approaches include drug administration, the reduction of neuroinflammation, neuromodulation with physical factors and in vivo reprogramming.
Permanent Link: https://hdl.handle.net/11104/0340110