Self-assembled nanoscale materials for neuronal regeneration: a focus on BDNF Protein and nucleic acid biotherapeutic delivery

0567933 - FZÚ 2023 RIV CH eng J - Journal Article
Wu, Y. - Rakotoarisoa, M. - Angelov, Borislav - Deng, Y. - Angelova, A.
Self-assembled nanoscale materials for neuronal regeneration: a focus on BDNF Protein and nucleic acid biotherapeutic delivery.
Nanomaterials. Roč. 12, č. 13 (2022), č. článku 2267. E-ISSN 2079-4991
R&D Projects: GA MŠMT EF15_003/0000447; GA MŠMT EF16_019/0000789
Grant - others:OP VVV - ELIBIO(XE) CZ.02.1.01/0.0/0.0/15_003/0000447; OP VVV - ADONIS(XE) CZ.02.1.01/0.0/0.0/16_019/0000789
Institutional support: RVO:68378271
Keywords : neuroprotective assemblies * brain-derived neurotrophic factor (BDNF) * nanomedicine for growth factor delivery
OECD category: Fluids and plasma physics (including surface physics)
Impact factor: 5.3, year: 2022
Method of publishing: Open access

Enabling challenging applications of nanomedicine and precision medicine in the treatment of neurodegenerative disorders requires deeper investigations of nanocarrier-mediated biomolecular delivery for neuronal targeting and recovery. The successful use of macromolecular biotherapeutics (recombinant growth factors, antibodies, enzymes, synthetic peptides, cell-penetrating peptide–drug conjugates, and RNAi sequences) in clinical developments for neuronal regeneration should benefit from the recent strategies for enhancement of their bioavailability. We highlight the advances in the development of nanoscale materials for drug delivery in neurodegenerative disorders. The emphasis is placed on nanoformulations for the delivery of brain-derived neurotrophic factor (BDNF) using different types of lipidic nanocarriers (liposomes, liquid crystalline or solid lipid nanoparticles) and polymer-based scaffolds, nanofibers and hydrogels.
Permanent Link: https://hdl.handle.net/11104/0339215